The Group B Streptococcal Serine‐Rich Repeat 1 Glycoprotein Mediates Penetration of the Blood‐Brain Barrier

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The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier.

BACKGROUND Group B Streptococcus (GBS) is the leading cause of bacterial meningitis in newborn infants. Because GBS is able to invade, survive, and cross the blood-brain barrier, we sought to identify surface-expressed virulence factors that contribute to blood-brain barrier penetration and the pathogenesis of meningitis. METHODS Targeted deletion and insertional mutants were generated in dif...

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Group B Streptococcal Sepsis in a Newborn: a Case Report

Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment wit...

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Group B Streptococcal Infections.

Group B streptococcal disease remains a prominent cause of infectious morbidity in pregnant women and their infants. This article highlights recent developments that are relevant for obstetricians, perinatologists, and neonatologists caring for patients with group B streptococcal disease. The morbidity of group B streptococcal infections in pregnancy and the proposed association of colonization...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2009

ISSN: 0022-1899,1537-6613

DOI: 10.1086/598217